The mission of the Southern HIV and Alcohol Research Consortium (SHARC) is to improve health outcomes and reduce HIV transmission among the diverse range of populations affected by alcohol and HIV infection in the Southeastern United States. Within this mission, SHARC is focusing on persons living in Florida, a state with high HIV incidence, substantial population diversity, and a high number of older persons living with HIV. To fulfill this mission, SHARC will foster translational, interdisciplinary research by providing research infrastructure, training and mentoring.